The Biobank Rare Variant Analysis (BRaVa) consortium, is a collaboration with the goal of bringing together analysts from global biobanks and cohorts to aggregate and analyse rare (coding) variant associations in WES/WGS data.

We will work to harmonise calling, QC, and data handling to generate robust associations for a set of well curated phenotypes put forward by members of the consortium.

BRaVa will enhance the power of rare variant association testing, enable the cross-validation of results, and facilitate the analysis of understudied diseases/disorders and traits, particularly those too rare to study in an individual cohort.

BRaVa is open and collaborative. If you’d like to join us, ping us an e-mail at